pill

Weight-Loss Bonus: Costs for Obesity-Related Meds Drop

Marlene Busko
November 18, 2013

Obese patients who successfully shed pounds by following a medical weight-loss program may reap the reward of lower medication costs for common comorbidities, new research suggests. The single-center, retrospective study was presented in an oral presentation at Obesity 2013: The Obesity Society Annual Scientific Meeting.

After following the program for an average of 22 weeks, patients who typically had a starting weight of about 250 pounds lost about 44 pounds. They also spent, on average, $70 less a month for medications for 4 common comorbidities: diabetes, hyperlipidemia, hypertension, and gastroesophageal reflux disease (GERD).

This shows that “weight loss in a medically supervised setting has the potential to significantly decrease the medication expenses associated with obesity comorbidities, most of all diabetes,” Clay P. Wiske, a medical student currently at Harvard Business School, in Boston, Massachusetts, told the audience.

“There hasn’t been very much published on the cost of medical weight-management programs…partly because [the programs are] not very homogeneous,” senior author Vincent Pera, MD, from Brown University in Providence, Rhode Island, told Medscape Medical News. “My guess is that no matter how the weight loss is achieved [including by bariatric surgery], you would see these kinds of benefits in medication reduction.”

The research was about “medication cost savings” as opposed to “cost-effectiveness,” he acknowledged, and the calculations did not include the cost of participating in the 5-month program, which was about $2000 per patient. About 2 or 3 insurance companies cover the entire cost, he noted.

The latest obesity guidelines, issued by the Obesity Society last week, stress medically supervised programs as a central tenet for successful weight loss, emphasizing that the evidence shows patients need help to shed the pounds. However, this type of program is very poorly reimbursed at present, at least by the Centers for Medicaid & Medicare Services (CMS) — at a rate of around $20 a visit. Coverage of such programs by private insurers in the United States is patchy; it is hoped the new recommendations will encourage more of them to reimburse such schemes.
Can “Low-Risk” Strategies Cut Costs?

Mr. Wiske told the audience that because many recent studies have looked at potential cost savings following bariatric surgery, “we were curious to see whether we would see savings with interventions that were less risky, such as medically supervised weight loss.”

On average, an obese adult living in the United States pays an estimated $2460 more in annual healthcare costs than his or her thinner counterparts, he said. The researchers hypothesized that the medically supervised weight-loss program offered at the Merriam Hospital in Providence, Rhode Island would lead to a decrease in medication costs.

They retrospectively analyzed data from 589 obese patients who participated in this program between 2009 and 2012 and, importantly, completed at least 16 weeks of treatment.

The patients had a mean age of 49 years and 70% were women. When they entered the program, they were taking an average of 4.6 medications, of which 1.6 were for the studied 4 comorbidities.

At baseline, half of the patients had hypertension, 47% had hyperlipidemia, 44% had GERD, and 20% had diabetes. Some patients did not have any of these comorbidities.

When they enrolled, the patients received counseling about 3 types of 1200-calorie-a day meals:

  • Complete meal replacement.
  • 800 calories from meal replacements plus one “regular” meal.
  • No meal replacements, but instead, a tailored, healthy diet.

The meal replacements were Optifast (Nestle) products, most commonly shakes, said Mr. Wiske. About 20% of patients did not take meal replacements, and the rest were split between the 2 types of meal-replacement plans.
All patients were offered weekly physician visits, weekly weigh-ins, counseling sessions with a dietician and an exercise physiologist, plus group education and discussion sessions.

On average, the patients lost about 17.5% of their initial body weight. The weight loss and medication reduction were similar for the patients in the 3 groups.

The average overall monthly wholesale cost of the studied medications fell from $150 to $77, with the largest reduction coming from the drop in cost of diabetes medications.

A multivariate linear model adjusted for physician visits demonstrated that total weight loss, number of nutrition and exercise counseling sessions attended, previous diagnosis of hypertension and hyperlipidemia, as well as number of initial medications were all positively correlated (P < .05) with percent decrease in monthly wholesale medication costs.
Longer Study Needed

“Future research should focus on the longevity of this effect and should include all healthcare costs,” Mr. Wiske concluded.

In response to a question asking how they were able to get people who weigh 250 pounds to stick to a 1200-calorie diet, he explained that the patients were all highly motivated, and some had entered the program because it was a prerequisite for surgery.

Asked to comment, session moderator Ken Fujioka, MD, from Scripps Clinic, San Diego, California, observed that although this was a retrospective study, “still, it had some interesting points — it showed that if you get weight loss, you can save some money…you save medication cost and you get somebody healthy.” However, the study was short and did not examine all costs.

And recent studies looking at bariatric surgery have been unable to prove long-term overall healthcare cost savings, he noted.

Obesity 2013: The Obesity Society Annual Scientific Meeting. Oral presentation, presented November 14, 2013.

diabetes

Current BMI Cutoffs May Miss Metabolic Disease Risk

Marlene Busko
November 14, 2013

ATLANTA — About a third of men and almost half of women classed as nonobese based on body mass index (BMI) alone had a high percentage of body fat; moreover, they were 10 times more likely to have metabolic syndrome than their peers, researchers report. In addition, gauging risk based on sedentary behavior alone may be misleading, they discovered.

The new findings, based on data from the 2003–2006 National Health and Nutrition Examination Survey (NHANES), were presented in a poster here at Obesity 2013: The Obesity Society Annual Scientific Meeting.

“BMI is potentially missing a lot of people who are at risk,” since they have “normal-weight obesity,” lead author Mark D. Peterson, PhD, from the University of Michigan, Ann Arbor, told Medscape Medical News.

Dr. Peterson does not believe that the BMI threshold to detect obesity will ever be lowered from 30 kg/m2. But he hopes the study results will draw attention to a segment of the population that might be missed when screening for disease risk if waist circumference or percentage of body fat is not considered.
The study also suggests that overall level of physical activity, not time spent being sedentary, is the better predictor of metabolic syndrome, say he and his colleagues.
Does BMI Accurately Predict Metabolic Syndrome?

The best way to screen for obesity, risk for cardiovascular disease, and diabetes remains controversial, and misclassification is common, the researchers explain. While BMI is used as a surrogate marker for adiposity to screen people, it does not distinguish between fat and muscle, Dr. Peterson pointed out.

In addition, time spent being sedentary is believed to contribute to risk for preventable disease and mortality, which is a growing topic of interest, he noted.

To investigate these 2 aspects of screening, the researchers analyzed data from 5576 participants of the 2003–2006 NHANES who were 20 to 85 years old and for whom data were available detailing blood pressure, measures of BMI, waist circumference, body fat, and activity levels.

Nonfasting serum measures of HDL cholesterol and high-sensitivity C-reactive-protein (hs-CRP) concentrations were also taken, as were fasting measures for triglycerides, plasma glucose, and insulin. Metabolic syndrome was defined as the presence of any 3 or more of the following:
 Abdominal obesity (> 102 cm for men; > 88 cm for women).
 Elevated triglycerides (> 1.7 mmol/L).
 Reduced HDL cholesterol (< 1.0 mmol/L in men; < 1.3 mmol/L in women).
 Hypertension (> 130 mm Hg systolic and/or > 85 mm Hg diastolic).
 Elevated fasting glucose (> 100 mg/dL).

Total body fat percentage was based on dual-energy X-ray absorptiometry readings, and obesity was defined as body fat of 25% or more for men and 35% or more for women.

Activity levels were based on 4 days of measurements from an accelerometer, which is a small device worn attached to the hip that is similar to a pedometer but that also counts movement intensity, Dr. Peterson explained.

A Very Obese Nation

BMI readings of 30 kg/m2 and above had excellent specificity in both men and women but very poor sensitivity; based on this cutoff, 30.6% of men and 37.5% of women were defined as being obese. Using body-fat percentage instead, the researchers found that 71.1% of men and 79.6% in women in this representative national population sample would be classed as obese (P < 0.001).

And 32.8% of the men and 45.7% of the women with a normal weight based on BMI measurements (18.5–24.9 kg/m2) were identified as obese according to body-fat percentage.

While less than a fifth of the men (17.5%) and women (16.7%) surveyed had metabolic syndrome, those who were classed as obese according to percentage of body fat had about a 10-fold increased likelihood of metabolic syndrome (odds ratio [OR], 9.64 for men; OR, 10.58 for women).

Age, education, percentage of body fat and being in the highest quartile for sedentary behavior (> 9.5 hours for men and > 9.25 hours for women) were all significantly associated with higher odds of having metabolic syndrome. Lower annual income was an independent predictor of metabolic syndrome for women only.

However, after adjustment for overall total activity, sedentary behavior was no longer associated with an increased risk for metabolic syndrome.

Use a BMI of 27.5 to Define Obesity?

“Dr. Peterson has some evidence that maybe we should be using a [BMI] cut point of 27 to 28 — and anything above that would be obese — which correlates better with body-fat percentage than the cut point of 30,” William D, Johnson, PhD, from Pennington Biomedical Research Center, Baton Rouge, Louisiana, pointed out when asked to comment. He himself has a BMI of 30 kg/m2, he noted, which brings this study close to home.

“If people would accept that cut point, that would redefine BMI,” he added, but like Dr. Peterson, he does not think that is likely, although some underdeveloped countries where people are very lean do use a lower BMI to define obesity, he noted.

This study was supported in part by the National Institutes of Health National Center for Medical Rehabilitation Research, National Institute on Neurological Disorders and Stroke, and National Institute on Aging.

sugar

New Study Suggests That High Blood Sugar Is Tied to Memory Problems

A recent study published in Neurology, a highly cited and peer-reviewed neurology journal, suggests that elevated blood sugar, even if it isn’t at a level considered “unhealthy,” can lead to memory loss.

German researchers conducting the study wanted to look further into the association between high blood sugar and memory loss after previous studies have shown that people with Type 2 diabetes may have an increased risk of developing dementia, a condition that causes people to suffer symptoms of cognitive decline such as forgetfulness and issues with speech and clear thinking.  Diabetes causes unhealthy elevated levels of glucose (sugar) in the bloodstream due to a body’s inability to recognize and use insulin to absorb glucose.

The study involved 143 people with an average age of 63 who did not have diabetes or pre-diabetes. People who were overweight, consumed more than 3.5 servings of alcohol daily and/or currently suffered from symptoms of memory impairment also were excluded from the study. After fasting for at least 10 hours, the participants had their glucose levels tested and an MRI image taken of their brains to determine the size of their hippocampi, a region of the brain linked to memory. They were then asked to perform a series of memory tests.

The results showed that those who had lower blood sugar levels obtained higher scores on the memory tests. When comparing the results with the scans of the participants’ hippocampi, the researchers further concluded that the “DTI-based (diffusion tensor imaging) measurements demonstrated that not only the volume of the hippocampus, but also the microstructural integrity is lower if blood sugar levels are higher.”

This means that people with higher blood sugar levels – even if they still fall within a range considered “healthy” – have hippocampi that do not function as efficiently as people with lower blood sugar levels and have less capable memories.

People with weights that fall into the obesity range and those over the age of 55 are most at risk of developing memory loss and cognitive impairment and should especially take note of these findings.

Blood sugar levels can be regulated with medication if necessary, but they can also be controlled naturally. Here are a few ways to keep the body’s blood sugar at optimum levels:

  • Exercise regularly, including both cardio and strength training workouts.
  • Eat diets rich in “low glycemic index” fruits, vegetables, lean proteins and whole grains.
  • Maintain a healthy weight.
  • Manage stress.

In addition, study author Dr. Agnes Flöel recommends that those who are most at risk for developing dementia have regular medical checks that include monitoring of fasting glucose and HbA1c levels so that any issues with blood sugar levels will be detected early and treated immediately.

The Medical and Surgical Clinic of Irving is here to serve patients interested in proactively avoiding potential memory loss or other health issues related to high blood sugar. Schedule an appointment with a member of our highly experienced Family Medicine physicians today to take charge of your long-term health.

Resources

http://www.neurology.org/

http://www.webmd.com/alzheimers/news/20081230/high-blood-sugar-linked-memory-loss

http://www.medicalnewstoday.com/articles/267727.php

http://www.nbcnews.com/health/high-blood-sugar-tied-memory-problems-8C11461282

http://www.reuters.com/article/2013/10/24/us-high-blood-sugar-idUSBRE99N1D220131024

diabetes

November Is National Diabetes Awareness Month

Learn More About Diabetes and How Medical and Surgical Clinic of Irving Is Actively Combating the Disease

Diabetes is a disease that affects the body’s ability to produce or recognize insulin, which in turn causes issues with proper management of the blood’s glucose (or sugar) levels. Insulin is a hormone that allows for the body’s cells to absorb glucose and use it for energy.

When the body is unable to use glucose for energy due to a lack of insulin or its inability to recognize insulin, the body’s cells become starved for energy. Left untreated, this can lead to serious health issues including heart attack, stroke, blindness or, in very severe cases, mild or severe nerve damage that may eventually require amputation. Nearly 26 million adults and children in the U.S. have the disease in one of its variety of forms: gestational diabetes, type 1 diabetes and type 2 diabetes.

Understanding the Different Types of Diabetes

Gestational diabetes is developed by some women during pregnancy, often around the 24th week. Those who are diagnosed with gestational diabetes did not necessarily have diabetes prior to their pregnancy and will not necessarily have diabetes after giving birth. It is important for them to follow their doctor’s advice on glucose levels throughout the pregnancy to promote the best health for themselves and their babies. Unlike with other forms of diabetes, it is possible that gestational diabetes will only last the duration of the pregnancy and will not be a lifelong illness.

Type 1 diabetes is a disease caused by the pancreas’ total inability to produce insulin. This type of the disease is most common in children but also affects adults. Only 5 percent of people in the U.S. with diabetes have type 1 diabetes. Type 1 diabetes can be easily managed with doctor recommended insulin therapy and a variety of additional medical treatments.

Type 2 diabetes is the most serious and most common form of the disease.  Those who suffer from Type 2 diabetes produce too much insulin due to what’s called “insulin resistance.” This means that the body’s cells are unable to properly use that insulin to absorb glucose for energy. People with Type 2 diabetes require a doctor’s uniquely tailored treatment plans and regular blood sugar and cholesterol level monitoring to successfully combat the disease as effectively as possible.

Steps to Take to Start Managing Symptoms Today

Although there is no cure for diabetes types 1 and 2, there are simple life changes that people can make to help mitigate their symptoms. Here are a few ways to combat diabetes that, partnered with a medical treatment plan, can help patients to take control of their symptoms so that they can get back to enjoying their lives.

  • Stay at a healthy weight.  Avoiding processed foods and simple sugars while choosing “low glycemic index” fruits and vegetables and lean proteins can help with this.
  • Get moving with some light or vigorous cardio workouts three to five times weekly.
  • Do something twice a week to increase muscle strength.
  • Wash hands frequently to avoid illness. Those with diabetes are affected more seriously by viruses such as the flu or a cold, so it’s important to keep as healthy as possible.
  • Stop or don’t start smoking or using tobacco.

How Medical and Surgical Clinic of Irving Helps Patients Fight Diabetes

Although taking the steps above will help to minimize the negative symptoms of diabetes, it’s still necessary for those with the disease to regularly see a doctor for checkups to ensure that blood sugar and cholesterol levels are remaining normal and that serious symptoms of the disease do not go untreated.

The expert family medicine, internal medicine and endocrinology physicians at Medical and Surgical Clinic of Irving are available to schedule appointments for diabetes assessments and recommend ongoing treatment plans. Visit our specialties page to learn more about the experienced practitioners available to assist patients with diabetes by monitoring their illness and proactively treating its symptoms. Read through each physician’s biography to discover more about their experience treating diabetes.

Resources

http://www.cdc.gov/features/livingwithdiabetes/

http://www.diabetes.org/

http://www.diabetes.org/in-my-community/programs/american-diabetes-month/